I 've install a turnkey MySQL Appliance few days ago on ESXi 4 u1 box. Everything worked well. I've turn the MTU of the eth0 adapter to 9000, the ESXi 's NIC is a GB one and Jumbo frame is enable.
Since I can not connect to MySQL from other VM !! The management interfaces and Web shellInAbox are unreachable too. Setting back the MTU to 1500 correct the problem .
From a physical PC, everything work fine with or without the MTU set to 9000.
What is wrong ?
PS: Sorry for my english, I'm french spoken