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Multiple Turnkey Instances
I have a Windows 2008 / VMware server running a couple of instances of Turnkey. Would it be more efficient to run one instance and install the other apps (ex> drupal, wordpress, joomla) then to have a separate instance for each. I try to keep the memory low for each around 128mb.
OTOH, if all applications are on the same server there is only one copy of the OS to maintain and you're going to use resources such as memory more efficiently. It usually doesn't matter nowadays for most usage scenarios though.